Insmed Innovation UK Ltd, formerly Adrestia Therapeutics, is a leader in synthetic rescue therapies for genetically defined diseases and is part of Insmed Incorporated, a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.

We are looking to hire a qualified individual to join our growing Human Genetics team at Insmed. As a member of our team, you will apply your expertise in statistical genetics / bioinformatics to conduct exciting research supporting our proprietary Synthetic Rescue technology platform. As part of your role, you will leverage datasets consisting of hundreds of thousands of humans to identify novel therapeutic targets and collaborate with our extensive wet lab team to drive these targets to the clinic.

Additional representative responsibilities will include, but not necessarily be limited to, the following: 

• Work with the human genetics leadership to identify potential areas of interest for future research programs
• Conduct research on ‘Synthetic Rescue’ at the direction of the human genetics leadership team
• Gain access to, curate multi-omics data from, and analyze diverse publicly available data from large biobank studies
• Develop human genetic analysis workflows both locally and in cloud-based environments
• Perform ad hoc analyses and function as a subject leader in support of ongoing wet lab / informatics projects
• Partner with the informatics team to ensure reproducible informatic workflows

Required Skills:

• PhD (or equivalent experience) and 3+ years of academic postdoc or industry experience in genetics, bioinformatics, medicine, biology, biostatistics, genetic epidemiology, or similar area.
• Experience using common statistical tests and methods for genetic association (e.g. GWAS, gene burden tests, regenie, BOLT-LMM)
• Experience in visualization of genetic data (e.g., Integrative Genomics Viewer)
• Experience building or implementing scalable human genetics pipelines to perform high-throughput analysis of hundreds of thousands of individuals
• Comfortable working in a Linux or Linux-like environment (e.g., bash / shell / MacOS)
• Proficiency in Python and R
• Strong data processing, quality control, and management skills
• Proven track record taking human genetics projects from concept to completion

Preferred Skills:

• Knowledge of common bioinformatics and next generation sequencing processing and analysis workflows (e.g., GATK, bwa, plink)
• Understanding of DNANexus, the UK Biobank Research Access Platform (RAP), or remote / cloud environments (e.g., AWS / gcloud / Microsoft Azure)
• Knowledge of generalized linear modeling, simulation of data, and design of ad hoc statistical tests
• Familiarity with wet-lab approaches for validation of human genetics targets
• Knowledge of Proteomics methods and workflows (e.g., SOMALogic / O-Link)
• Strong presentation, visualization, and communication skills

Attendance at international conference will be included as part of this role.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.