Insmed Innovation UK Ltd, formerly Adrestia Therapeutics, is a leader in synthetic rescue therapies for genetically defined diseases and is part of Insmed Incorporated, a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.

We are seeking an innovative and self-motivated medicinal chemist to join our chemistry leadership team, contributing to team growth and the formulation of the chemistry strategy. This role plays a pivotal part in translating our groundbreaking biological discoveries into pioneering small molecule and oligonucleotide medicines. It presents an outstanding opportunity to thrive within an exciting, next-generation therapeutics environment. The work pace is dynamic, swift, and engaging.

Additional representative responsibilities will include, but not necessarily be limited to, the following: 

• Assume a vital role as a chemistry leader, contributing to the establishment of a cutting-edge medicinal chemistry group
• Lead drug discovery projects. Provide clear program strategy and timely, efficient delivery of candidate molecules of exceptional quality through scientific rigour and high-quality compound design
• Apply efficient and effective methodologies to complete hit-to-candidate medicinal chemistry campaigns to the highest standards and in short timescales
• Implement cutting-edge in-silico techniques to drive drug design
• Initiate and manage CRO collaborations to execute on multidisciplinary discovery activities

• Line manages members of the chemistry team

• Present at and contribute to internal company scientific and strategic review panels
• Compile candidate selection data packages and contribute to IND documentation
• Maintain competitive awareness for projects
• Be aware of external technology developments and opportunities for collaboration to enhance the development of company capabilities
• Oversee compilation and filing of patent applications
• Identify opportunities to publish chemistry-related company results
• Assist in establishing safe and effective working practices in company laboratories

• A PhD in organic chemistry
• 5+ years' experience in a medicinal chemistry role within biotech or pharma
• Track record of leading drug discovery projects to successful outcomes from hit ID to clinical candidate
• Demonstrated flair for structure-based drug design
• Creative problem-solving approach to typical medicinal chemistry challenges including ADME, physicochemical properties, safety pharmacology
• Strong verbal and written communication skills to communicate complex concepts to diverse audiences
• A strong sense of urgency and focus to deliver successful outcomes
• Up to date awareness of latest technology developments in drug design, synthesis and testing
• Experience of leading interdisciplinary or functional teams
• Demonstrated ability to mentor and develop scientists
• Significant track record of publications and patents

Some travel to visit other Insmed sites and CRO partners

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.